Step 1: Write second polynomial below the first one. Making sure like terms are lined up.
$$ \begin{array}{lrrr} & 2x^2 & 8x & 4 \\ \color{red}{ - } & 8x^2 & -8x & \\ \hline \end{array} $$Step 2: Change ALL the signs in the second row.
$$ \begin{array}{lrrr} & 2x^2 & 8x & 4 \\ \color{red}{ - } & -8x^2 & 8x & \\ \hline \end{array} $$Step 3: Combine like terms (add each column):
$$ \begin{array}{lrrr} & 2x^2 & 8x & 4 \\ \color{red}{ - } & -8x^2 & 8x & \\ \hline & 10x^2 & & 4 \end{array} $$