Step 1: Write second polynomial below the first one. Making sure like terms are lined up.
$$ \begin{array}{lrrrr} & 25x^4 & & & -49 \\ \color{red}{ - } & 8x^4 & 12x^3 & 8x & 12 \\ \hline \end{array} $$Step 2: Change ALL the signs in the second row.
$$ \begin{array}{lrrrr} & 25x^4 & & & -49 \\ \color{red}{ - } & -8x^4 & -12x^3 & -8x & -12 \\ \hline \end{array} $$Step 3: Combine like terms (add each column):
$$ \begin{array}{lrrrr} & 25x^4 & & & -49 \\ \color{red}{ - } & -8x^4 & -12x^3 & -8x & -12 \\ \hline & 33x^4 & 12x^3 & 8x & -37 \end{array} $$