We can use distribution property to multiply the polynomial by the monomial.
$$ \begin{aligned} \color{blue}{21331324201} \cdot \left( 2x+5 \right) &= \color{blue}{21331324201} \cdot 2x + \color{blue}{21331324201} \cdot 5 = \\ &= 42662648402x+106656621005 \end{aligned} $$